PUBLICATIONS   D Diez, ÅM Wheelock, S Goto, JZ Haeggström, G Paulsson-Berne, GK Hansson, U Hedin, A Gabrielsen, CE Wheelock, 2010. The use of network analyses for elucidating mechanisms in cardiovascular disease. Molecular BioSystems 6(2):289-304 Supporting Information Issue Cover       L Folkersen, D Diez, CE Wheelock, JZ Haeggström, S Goto, P Eriksson, A Gabrielsen, 2009. GeneRegionScan: A Bioconductor package for probe level analysis of specific, small regions of the genome. Bioinformatics 25(15):1978-1979       CE Wheelock, ÅM Wheelock, S Kawashima, D Diez, M Kanehisa, M van Erk, R Kleemann, JZ Haeggstrom, S Goto, 2009. Systems biology approaches and pathway tools for investigating cardiovascular disease. Molecular BioSystems 5(6):588-602. Supporting Information       T Harada, Y Nakagawa, RM Wadkins, PM Potter, CE Wheelock, 2009. Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis. Bioorganic and Medicinal Chemistry 17(1):149-164.       CN Hayes, D Diez, N Joannin, W Honda, M Kanehisa, M Wahlgren, CE Wheelock, and S Goto, 2008. varDB: a pathogen-specific sequence database of protein families involved in antigenic variation. Bioinformatics 24(21):2564-2565       JC Sanchez-Hernandez and CE Wheelock, 2008. Tissue distribution, isozyme abundance and sensitivity to chlorpyrifos-oxon of carboxylesterases in the earthworm Lumbricus terrestris. Environmental Pollution 157(1):264-272.       CE Wheelock, ME Colvin, JS Sanborn, and BD Hammock, 2008. Substituted 3-phenylpropenoates and related analogs: Electron ionization mass spectral fragmentation and density functional theory calculations. Journal of Mass Spectrometry 43(8):1053-1062.   C Morisseau, JW Newman, CE Wheelock, T Hill, D Morin, AR Buckpitt, and BD Hammock, 2008. Development of metabolically stable inhibitors of mammalian microsomal epoxide hydrolase. Chemical Research in Toxicology 21(4):951-957.   CE Wheelock, J Forshed, S Goto, BD Hammock, and JW Newman, 2008. Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chemical Research in Toxicology 21(3):583-590. Supporting Information   CE Wheelock, K Nishi, A Ying, PD Jones, ME Colvin, MM Olmstead, and BD Hammock, 2008. Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). Bioorganic and Medicinal Chemistry 16(4):2114-21130. Article featured on journal cover cover   CJ Hillard, W-S V Ho, J Thompson, K M Gauthier, CE Wheelock, H Huang and BD Hammock, 2007. Effects of catabolic inhibitors on vasodilation of rat middle cerebral artery by the endocannabinoid, 2-arachidonylglycerol. British Journal of Pharmacology 152(5):691-698.   T Kadowaki, CE Wheelock, T Adachi, T Kudo, S Okamoto, N Tanaka, K Tonomura, G Tsujimoto, H Mamitsuka, S Goto, and M Kanehisa, 2007. Identification of endocrine disruptor biodegradation by integration of structure-activity relationship with pathway analysis. Environmental Science and Technology 41:7997-8003. Supporting Information   CE Wheelock, S Goto, BD Hammock, and JW Newman, 2007. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice. Metabolomics 3(2):137-145. Supporting Information   MP Endsley, MA Isbell, L Cui, CE Wheelock, BD Hammock, JR Falck, WB Campbell, and K Nithipatikom, 2007. Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism. International Journal of Cancer 121(5):984-991.   RM Wadkins, JL Hyatt, CC Edwards, L Tsurkan, MR Redinbo, CE Wheelock, PD Jones, BD Hammock, and PM Potter, 2007. QSAR analysis of trifluoromethylketone-mediated inhibition of mammalian carboxylesterases. Molecular Pharmacology 71(3):713-723.   J Normark, D Nilsson, U Ribacke, G Winter, K Moll, CE Wheelock, J Bayarugaba, F Kironde, TG Egwang, Q Chen, B Andersson, and M Wahlgren, 2007. PfEMP1 motifs predict severity of Plasmodium falciparum malaria. PNAS 104(40):15825-15840. Supporting Information Commentary   M Wogulis, CE Wheelock, SG Kamita, AC Hinton, PA Whetstone, BD Hammock, and DK Wilson, 2006. Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta. Biochemistry 45(13):4045-4057.   CE Wheelock, JL Miller, MJ Miller, BM Phillips, SA Huntley, SJ Gee, RS Tjeerdema, and BD Hammock, 2006. Evaluation of esterase activity for use in removal of pyrethroid-associated toxicity to Ceriodaphnia dubia and Hyalella azteca. Environmental Toxicology and Chemistry 25(4):973-984.   CE Wheelock, Y Nakagawa, T Harada, N Oikawa, M Akamatsu, G Smagghe, D Stefanou, K Iatrou, and L Swevers, 2006. High-throughput screening of ecdysone agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity. Bioorganic & Medicinal Chemistry 14(4):1143-1159.   K Kang, PD Jones, H Huang, R Zhang, LA Mostovich, CE Wheelock, T Watanabe, LF Gulyaeva, and BD Hammock, 2005. Evaluation of a-cyanoethers as fluorescent substrates for assay of cytochrome P450 enzyme activity. Analytical Biochemistry 344(2):183-192.   CE Wheelock, K Eder, I Werner, H Huang, PD Jones, BF Brammell, AA Elskus, and BD Hammock, 2005. Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos. Aquatic Toxicology 74(2):172-192.   K. Nithipatikom, MP Endsley, MA Isbell, CE Wheelock, BD Hammock, and WB Campbell, 2005. A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells. Biochemical and Biophysical Research Communications 332(4):1028-1033.   CE Wheelock, JL Miller, MJ Miller, BM Phillips, SJ Gee, RS Tjeerdema, and BD Hammock, 2005. Influence of container adsorption upon observed pyrethroid toxicity to Ceriodaphnia dubia and Hyalella azteca. Aquatic Toxicology 74(1):47-52.   CE Wheelock, JL Miller, MJ Miller, SJ Gee, G Shan, and BD Hammock, 2004. Development of Toxicity Identification Evaluation (TIE) procedures for pyrethroid detection using esterase activity. Environmental Toxicology and Chemistry 23(11):2699-2708.   JE Stok, A Goloshchapov, C Song, CE Wheelock, MBH Derbel, C Morisseau, and BD Hammock, 2004. Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis. Archives of Biochemistry and Biophysics 430(2):247-255.   JE Stok, H Huang, PD Jones, CE Wheelock, C Morisseau, and BD Hammock, 2004. Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes. Journal of Biological Chemistry 279(28):29863-29869.   RD McAbee, KD Kang, MA Stanich, J Christiansen, CE Wheelock, A Inman, BD Hammock, and AJ Cornel, 2004. Pyrethroid tolerance in Culex pipiens molestus var molestus from Marin County, California. Pest Management Science 60:359-368.   CE Wheelock, Y Nakagawa, M Akamatsu, and BD Hammock, 2003. Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors. Bioorganic and Medicinal Chemistry 11(23):5101-5116.   CE Wheelock, ÅM Wheelock, R Zhang, JE Stok, C Morisseau, SE Le Valley, CE Green, and BD Hammock, 2003. Evaluation of a-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes. Analytical Biochemistry 315:208-222.   DL Denton, CE Wheelock, S Murray, LA Deanovic, BD Hammock, and DE Hinton, 2003. Joint acute toxicity of esfenvalerate and diazinon to fathead minnow (Pimephales promelas) larvae. Environmental Toxicology and Chemistry 22(2):336-341.   CE Wheelock, ME Colvin, I Uemura, MM Olmstead, Y Nakagawa, JR Sanborn, AD Jones, and BD Hammock, 2002. Use of ab initio calculations to predict carboxylesterase inhibitor potency. Journal of Medicinal Chemistry 45(25):5576-5593. Supporting Information   CE Wheelock, TA Baumgartner, JW Newman, MF Wolfe, and RS Tjeerdema, 2002. Effect of nutritional state on Hsp60 levels in the rotifer Brachionus plicatilis following toxicant exposure. Aquatic Toxicology 61(1-2):89-93.   C Morisseau, MH Goodrow, JW Newman, CE Wheelock, DL Dowdy, and BD Hammock, 2002. Structural refinement of urea based soluble epoxide hydrolase inhibitors. Biochemical Pharmacology 63(9):1599-1608.   CE Wheelock, TF Severson, and BD Hammock, 2001. Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. Chemical Research in Toxicology 14(12):1563-1572.   JW Newman, DL Denton, C Morisseau, CS Koger, CE Wheelock, DE Hinton, and BD Hammock, 2001. Evaluation of fish models of soluble epoxide hydrolase inhibition. Environmental Health Perspectives 109(1):61-66.   Y Nakagawa, CE Wheelock, C Morisseau, MH Goodrow, BG Hammock, and BD Hammock, 2000. 3-D Analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, aryl ureas, and their analogs. Bioorganic and Medicinal Chemistry 8(11):2663-2673.   CE Wheelock, MF Wolfe, H Olsen, M Sowby, and RS Tjeerdema, 1999. Hsp60 induced tolerance in the rotifer, Brachionus plicatilis, exposed to multiple environmental contaminants. Archives of Environmental Contamination and Toxicology 36(3):281-287.   CE Wheelock, MF Wolfe, H Olsen, and RS Tjeerdema, 1998. Characterization of hsp60 response in the rotifer, Brachionus plicatilis, exposed to multiple environmental contaminants. Marine Environmental Research 46:453-456.   Review Articles and Book Chapters   SL Lundström, FL D'Alexandri, K Nithipatikom, JZ Haeggström, ÅM Wheelock, CE Wheelock, 2009. HPLC/MS/MS based approaches for detection and quantification of eicosanoids. In “Lipidomics: Methods in Molecular Biology”. Editor: Donald Armstrong, Humana Press Inc, Totowa, New Jersey, USA 579:161-187.       CE Wheelock, S Goto, L Yetukuri, FL D’Alexandri, C Klukas, F Schreiber, and M Orešič, 2009. Bioinformatics strategies for the analysis of lipids. In “Lipidomics: Methods in Molecular Biology”. Editor: Donald Armstrong, Humana Press Inc, Totowa, New Jersey, USA 580:339-368.       D Diez, N Hayes, N Joannin, J Normark, M Kanehisa, M Wahlgren, CE Wheelock, S Goto, 2009. varDB: A database of antigenic variant sequences - Current status and future prospects. Acta Tropica (in press)       ÅM Wheelock and CE Wheelock, 2008. From Genome to Proteome: Integration and proteome completion - 8th Siena Meeting. IDrugs 11(11):799-802.       ÅM Wheelock and CE Wheelock, 2008. Bioinformatics in gel-based proteomics. In “Plant proteomics: Technologies, Strategies and Applications”. Editors: Ganesh Agrawal and Randeep Rakwal, Wiley InterScience, Hoboken, New Jersey, USA pp 107-125.   CE Wheelock, BM Phillips, BS Anderson, JL Miller, MJ Miller and BD Hammock, 2008. Applications of carboxylesterase activity in environmental monitoring and toxicity identification evaluations (TIEs). Reviews in Environmental Contamination and Toxicology 195:117-178 .   CE Wheelock, and H Miyagawa, 2006. Editorial: The omicsization of agriculture. Journal of Pesticide Science 31(3):240-244.   CN Hayes, ÅM Wheelock, J Normark, MC Wahlgren, S Goto, and CE Wheelock, 2006. Enlistment of omics technologies in the fight against malaria: Panacea or Pandora’s box? Journal of Pesticide Science 31(3):263-272.   T Kadowaki, CE Wheelock, M Hattori, S Goto, and M Kanehisa, 2006. Structure-activity relationships and pathway analysis of biological degradation processes. Journal of Pesticide Science 31(3):273-281.   CE Wheelock, G Shan, J Ottea, 2005. Overview of carboxylesterases and their role in the metabolism of insecticides. Journal of Pesticide Science 30(2):75-83.   M Lydy, J Beldin, CE Wheelock, BD Hammock, and DL Denton, 2004. Challenges in regulating pesticide mixtures. Ecology and Society 9(6):1. [online] URL: http://www.ecologyandsociety.org/vol9/iss6/art1.   SG Kamita, AC Hinton, CE Wheelock, MD Wogulis, DK Wilson, NM Wolf, B Hock, and BD Hammock, 2003. Juvenile hormone (JH) esterase: Why are you so JH specific? Insect Biochemistry and Molecular Biology 33(12):1261-1273.