FUNDING We gratefully acknowledge the support of our funders who have made this research possible. Swedish Heart-Lung FoundationCentrum för allergiforskning Karolinska InstitutetFredrik och Ingrid Thurings StiftelseEuropean Union FP6The Royal Swedish Academy of SciencesAke Wiberg StiftelseJeanssons StiftelserSwedish Foundation for Strategic ResearchJapanese Society for the Promotion of ScienceJapan International Science and Technology Policy Exchange CenterSwedish Research Council (VR)