Integrative Molecular Phenotyping
INTEGRATIVE MOLECULAR
PHENOTYPING
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY

Years

Publications

P Zhang, C Carlsten, R Chaleckis, K Hanhineva, M Huang, T Isobe, VM Koistinen, I Meister, S Papazian, K Sdougko, H Xie, JW Martin, SM Rappaport, H Tsugawa, DI Walker, TJ Woodruff, RO Wright, CE Wheelock, 2021. Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective. Environmental Science & Technology Letters. 8(10):839-852.
R Abdalkader, R Chaleckis, I Meister, P Zhang, CE Wheelock, KI Kamei, 2020. Untargeted LC-MS metabolomics for the analysis of micro-scaled extracellular metabolites from hepatocytes. Analytical Science. 37(7):1049-1052.
J Liu, J Kolmert, J Safholm, AK Johnsson, J Zurita, CE Wheelock, SE Dahlen, G Nilsson, M Adner, 2021. Distinct effects of antigen and Compound 48/80 in the guinea pig trachea. Allergy. 76(7):2270-2273.
FH Alahmadi, AJ Simpson, C Gomez, M Ericsson, JO Thorngren, C Wheelock, DE Shaw, LJ Fleming, G Roberts, J Riley, S Bates, AR Sousa, R Knowles, AT Bansal, J Corfield, I Pandis, K Sun, PS Bakke, M Caruso, P Chanez, B Dahlen, I Horvath, N Krug, P Montuschi, F Singer, S Wagers, IM Adcock, R Djukanovic, KF Chung, PJ Sterk, SE Dahlen, SJ Fowler, and the U-BIOPRED Study Group, 2021. Medication adherence in patients with severe asthma prescribed oral corticosteroids in the U-BIOPRED cohort. Chest. 160(1):53-64.
R Abdalkader, R Chaleckis, CE Wheelock, K Kamei, 2021. Spatiotemporal determination of metabolite activities in the corneal epithelium on a chip. Experimental Eye Research. 209:108646
A Alhamdow, A Zettergren, I Kull, J Hallberg, N Andersson, S Ekström, M Berglund, CE Wheelock, YJ Essig, AM Krais, A Georgelis, CH Lindh, E Melén, A Bergström, 2021. Low-level polycyclic aromatic hydrocarbon exposure is associated with reduced lung function in young adulthood. Environmental Research. 197:111169.
N Akawi, A Checa, AS Antonopoulos, I Akoumianakis, E Daskalaki, CP Kotanidis, H Kondo, K Lee, D Yesilyurt, I Badi, M Polkinghorne, N Akbar, J Lundgren, S Chuaiphichai, R Choudhury, S Neubauer, KM Channon, SS Torekov, CE Wheelock*, Charalambos Antoniades*, 2021. Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients with Cardiovascular Disease. Journal of American College of Cardiology. 77(20):2494-2513.
AK Johnsson, E Ronnberg, D Fuchs, J Kolmert, J Safholm, HE Claesson, M Hamberg, CE Wheelock, G Nilsson, SE Dahlen, 2021. COX-1 dependent biosynthesis of 15-hydroxyeicosatetraenoic acid in human mast cells. Biochim Biophys Acta Mol Cell Biol Lipids. 1866(5):158886.
J Kolmert, SE Dahlen, and CE Wheelock, 2021. Reply to Thomson: Exposure to Active and Passive Tobacco Smoke on Urinary Eicosanoid Metabolites in Type 2 Asthma. American Journal of Respiratory and Critical Care Medicine. 203(9):1204-1205.
YE Badi, AB Pavel, S Pavlidis, JH Riley, S Bates, NZ Kermani, R Knowles, J Kolmert, CE Wheelock, S Worsley, M Uddin, K Alving, PS Bakke, A Behndig, M Caruso, P Chanez, LJ Fleming, SJ Fowler, U Frey, P Howarth, I Horváth, N Krug, AH Maitland-van der Zee, P Montuschi, G Roberts, M Sanak, DE Shaw, F Singer, PJ Sterk, R Djukanovic, SE Dahlen, YK Guo, KF Chung, E Guttman-Yassky, and IM Adcock, and the U-BIOPRED study group, 2021. Mapping atopic dermatitis and anti-IL-22 response signatures to Type 2-low severe neutrophilic asthma. Journal of Allergy and Clinical Immunology. S0091-6749(21)00648-5.
D Rago, CT Pedersen, M Huang, RS Kelly, G Gurdeniz, N Brustad, H Knihtil, KA Lee-Sarwar, A Morin, MA Rasmussen, J Stokholm, K Bonnelykke, AA Litonjua, CE Wheelock, ST Weiss, J Lasky-Su, H Bisgaard, BL Chawes, 2021. Characteristics and Mechanisms of a Sphingolipid-associated Childhood Asthma Endotype. American Journal of Respiratory and Critical Care Medicine. 203(7):853-863.
AK Johnsson, JH Choi, E Ronnberg, D Fuchs, J Kolmert, M Hamberg, B Dahlen, CE Wheelock, SE Dahlen, and G Nilsson, 2021. Selective inhibition of prostaglandin D2 biosynthesis in human mast cells to overcome need for multiple receptor antagonists: Biochemical consequences. Clinical and Experimental Allergy. 51(4):594-603.
A Mazein, O Ivanova, I Balaur, M Ostaszewski, V Berzhitskaya, T Serebriyskaya, T Ligon, J Hasenauer, B De Meulder, RW Overall, L Roy, RG Knowles, CE Wheelock, SE Dahlen, KF Chung, IM Adcock, G Roberts, R Djukanovic, J Pellet, P Gawron, R Balling, AH Maitland-van der Zee, R Schneider, PJ Sterk, C Auffray, the U-BIOPRED Studu Group, 2021. AsthmaMap: An interactive knowledge repository for mechanisms of asthma. Journal of Allergy and Clinical Immunology. 147(3):853-6.
I Meister, P Zhang, A Sinha, CM Skold, AM Wheelock, T Izumi, R Chaleckis, CE Wheelock, 2021. High-Precision Automated Workflow for Urinary Untargeted Metabolomic Epidemiology. Analytical Chemistry. 93(12):5248-5258.
J Kolmert, C Gómez, D Balgoma, M Sjödin, M Eriksson, M Mikus, J-O Thörngren; AJ James, A Sousa, P Bakke, H Bisgaard, FK Chung, M Caruso, P Chanez, A D’Amico, SJ Fowler, T Geiser, P Howarth, I Horváth, N Krug, P Montuschi, J Musial, T Sandström, DE Shaw, I Pandis, R Knowles, R Djukanovic, B Dahlén, PJ Sterk, SE Dahlén, CE Wheelock, on behalf of the U-BIOPRED Study Group, 2020. Increased urinary leukotriene E4 and prostaglandin D2 metabolites in severe asthma and type-2 inflammation. American Journal of Respiratory and Critical Care Medicine, 203(1):37-53.
NZ Kermani, M Saqi, P Agapow, S Pavlidis, CH Kuo, KS Tan, S Mumby, K Sun, M Loza, F Baribaud, AR Sousa, J Riley, AM Wheelock, CE Wheelock, B De Meulder, J Schofield, S Sanchez-Ovando, JL Simpson, KJ Baines, PA Wark, C Auffray, SE Dahlen, PJ Sterk, R Djukanovic, IM Adcock, YK Guo, KF Chung, the U-BIOPRED Studu Group, 2021. Type 2-low asthma phenotypes by integration of sputum transcriptomics and serum proteomics. Allergy. 76(1):380-3.
JM Harder, C Guymer, JPM Wood, E Daskalaki, G Chidlow, C Zhang, R Balasubramanian, BH Cardozo, NE Foxworth, KE Deering, TB Ouellette, C Montgomery, CE Wheelock, RJ Casson, PA Williams, SWM John, 2020. Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin. Proceedings of the National Academy of Sciences U S A. 117(52):33619-33627.
S Eisinger, D Sarhan, VF Boura, I Ibarlucea-Benitez, S Tyystjärvi, G Oliynyk, M Arsenian-Henriksson, D Lane, SL Wikström, R Kiessling, T Virgilio, SF Gonzalez, D Kaczynska, S Kanatani, E Daskalaki, CE Wheelock, S Sedimbi, BJ Chambers, JV Ravetch, MCI Karlsson, 2020. Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells. Proceedings of the National Academy of Sciences U S A. 2020 Dec 15;117(50):32005-32016
I Tada, R Chaleckis, H Tsugawa, I Meister, P Zhang, N Lazarinis, B Dahlén, CE Wheelock, M Arita, 2020. Correlation-Based Deconvolution (CorrDec) To Generate High-Quality MS2 Spectra from Data-Independent Acquisition in Multisample Studies. Analytical Chemistry. 92(16):11310-11317.
SH Møller, M Mellergaard, M Madsen, AV Bermejo, SD Jepsen, MH Hansen, RI Høgh, BI Aldana, C Desler, LJ Rasmussen, EG Sustarsic, Z Gerhart-Hines, E Daskalaki, CE Wheelock, TK Hiron, D Lin, CA O'Callaghan, HH Wandall, L Andresen, S Skov, 2020. Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells. Frontiers in Immunology. 11:1968.

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