Integrative Molecular Phenotyping
INTEGRATIVE MOLECULAR
PHENOTYPING
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY

Years

Publications

M Sjödin, A Checa, M Yang, SE Dahlén, ÅM Wheelock, J Grunewald, CE Wheelock, 2018. Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis. Respiratory Research, 19(1):236.
A Lukic, C Wahlund, C Gomez, D Brodin, B Samuelsson, CE Wheelock, S Gabrielsson, Olof Rådmark, 2018. Exosomes from lung cancer pleura exudates promote cancer cell migration and survival via CysLT1. Cancer Letters. 444:1-8.
CX Li, CE Wheelock CE, CM Sköld, ÅM Wheelock, 2018. Integration of multi-omics datasets enables molecular classification of COPD. European Respiratory Journal. 51(5).
B Burla, M Arita, M Arita, AK Bendt, A Cazenave-Gassiot, EA Dennis, K Ekroos, X Han, K Ikeda, G Liebisch, MK Lin, T Ping Loh, PJ Meikle, M Orešič, O Quehenberger, A Shevchenko, F Torta, MJO Wakelam, CE Wheelock, and MR Wenk, 2018. Mass spectrometry-based lipidomics of human blood plasma - a community-initiated position paper aimed at developing generally accepted guidelines. 59(10):2001-2017.
A Mazein, RG Knowles, I Adcock, KF Chung, CE Wheelock, AH Maitland-van der Zee, PJ Sterk, C Auffray, 2018. AsthmaMap: An expert-driven computational representation of disease mechanisms; AsthmaMap Project Team. Clinical Experimental Allergy. 48(8):916-918.
M Dyszynski, M Vesterlund, AC Björklund, V Zachardias, J Janssen, H Gallart-Ayala, CE Wheelock, J Lehtiö, D Grandér, K Pokrovskaja Tamm, R Nilsson, 2018. Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment. Cell Death and Disease, 9(9):846.
A Mahdi, O Kövamees, A Checa, CE Wheelock, M von Heijne, M Alvarsson, J Pernow, 2018. Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose lowering therapy. Journal of Internal Medicine. 284(4):388-398.
SN Reinke, B Galindo-Prieto, T Skotare, DI Broadhurst, A Singhania, D Horowitz, R Djukanović, TSC Hinks, P Geladi, J Trygg, CE Wheelock, 2018. OnPLS-based multi-block data integration: a multivariate approach to interrogating biological interactions in asthma. Analytical Chemistry, in press.
D Fuchs, M Hamberg, CM Sköld, ÅM Wheelock, CE Wheelock, 2018. An LC-MS/MS workflow to characterize 16 regio- and stereoisomeric trihydroxyoctadecenoic acids (TriHOMEs). Journal Lipid Research. pii: jlr.D087429.
J Kolmert, A Fauland, D Fuchs, J Säfholm, C Gomez, M Adner, SE Dahlén, CE Wheelock, 2018. Lipid mediator quantification in isolated human and guinea pig airways – an expanded approach for respiratory research. Analytical Chemistry, 90(17):10239-10248.
R Chaleckis, I Meister, P Zhang, CE Wheelock, 2018. Challenges, progress and promises of metabolite annotation for LC–MS-based metabolomics. Current Opinion in Biotechnology, edited by Saulius Klimasauskas and Linas Mazutis. 55:44-50.
E Daskalaki, NJ Pillon, A Krook, CE Wheelock, A Checa, 2018. The influence of culture media upon observed cell secretome metabolite profiles: the balance between cell viability and data interpretability. Analytica Chimica Acta, 1037:338-350.
R Emma, AT Bansal, J Kolmert, CE Wheelock, SE Dahlén, MJ Loza, B De Meulder, D Lefaudeux, C Auffray, B Dahlén, PS Bakke, P Chanez, I Horvath, A Chaiboonchoe, H Ahmed, S Ballereau, C Rossios, KF Chung, P Montuschi, SJ Fowler, IM Adcock, AD Postle, A Rowe, PJ Sterk, R Djukanovic; the U-BIOPRED Study Group, 2018. Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort. PLoS One, 13(9):e0203874.
AC Araujo, CE Wheelock, JZ Haeggström, 2018. The eicosanoids, redox regulated lipid mediators in immunometabolic disorders. Antioxidants and Redox Signaling. 29(3):275-296.
A Laguna-Fernández, A Checa, M Carracedo, G Artiach, MH Petri, M Josefa Forteza, X Jiang, R Baumgartner, T Andonova, H Arnardottir, A Gisterå, S Thul, CE Wheelock, G Paulsson-Berne, D Ketelhuth, GK Hansson, M Bäck, 2018. CHEMR23 signaling protects from atherosclerosis by modifying oxLDL uptake and phagocytosis in macrophages. Circulation, in press. doi: 10.1161/CIRCULATIONAHA.117.032801
R Chaleckis, S Naz, I Meister, CE Wheelock, 2018. LC-MS based metabolomics of biofluids using all ion fragmentation (AIF) acquisition. Methods in Molecular Biology. Ed. Martin Giera. Springer Nature, 1730:45-58.
M Mittal, M Hasan, N Balagunaseelana, A Fauland, C Wheelock, O Rådmark, JZ Haeggström, and A Rinaldo-Matthis, 2017. Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase. Biochem Biophys Acta. 1861(8):2099-2111.
S Naz, J Kolmert, M Xing, SN Reinke, MA Kamleh, S Snowden, T Heyder, B Levänen, DJ Erle, M Sköld, ÅM Wheelock, and CE Wheelock, 2017. Metabolomics analysis identifies gender-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD. European Respiratory Journal, in press
SN Reinke, H Gallart-Ayala, C Gomez, A Checa, A Fauland, S Naz, MA Kamleh, R Djurvanovic, T Hinks, and CE Wheelock, 2017. Metabolomics analysis identifies different metabotypes of asthma severity. European Respiratory Journal, 49:1601740.
MH Petri, A Laguna-Fernandez, H Arnardottir, CE Wheelock, M Perretti, GK Hansson, M Bäck. Aspirin-triggered lipoxin inhibits atherosclerosis progression in ApoE-/- mice. British Journal of Pharmacology. 2017 Jan 10. doi: 10.1111/bph.13707

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