Integrative Molecular Phenotyping
INTEGRATIVE MOLECULAR
PHENOTYPING
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY

Years

Publications

K. Nithipatikom, MP Endsley, MA Isbell, CE Wheelock, BD Hammock, and WB Campbell, 2005. A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells. Biochemical and Biophysical Research Communications 332(4):1028-1033.
CE Wheelock, K Eder, I Werner, H Huang, PD Jones, BF Brammell, AA Elskus, and BD Hammock, 2005. Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos. Aquatic Toxicology 74(2):172-192.
CE Wheelock, JL Miller, MJ Miller, BM Phillips, SJ Gee, RS Tjeerdema, and BD Hammock, 2005. Influence of container adsorption upon observed pyrethroid toxicity to Ceriodaphnia dubia and Hyalella azteca. Aquatic Toxicology 74(1):47-52.
CE Wheelock, G Shan, J Ottea, 2005. Overview of carboxylesterases and their role in the metabolism of insecticides. Journal of Pesticide Science 30(2):75-83.
CE Wheelock, JL Miller, SJ Gee, G Shan, and BD Hammock, 2004. Development of Toxicity Identification Evaluation (TIE) procedures for pyrethroid detection using esterase activity. Environmental Toxicology and Chemistry 23(11):2699–2708.
JE Stok, H Huang, PD Jones, CE Wheelock, C Morisseau, and BD Hammock, 2004. Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes. Journal of Biological Chemistry 279(28):29863-29869.
RD McAbee, KD Kang, MA Stanich, J Christiansen, CE Wheelock, A Inman, BD Hammock, and AJ Cornel, 2004. Pyrethroid tolerance in Culex pipiens molestus var molestus from Marin County, California. Pest Management Science 60:359-368.
JE Stok, A Goloshchapov, C Song, CE Wheelock, MBH Derbel, C Morisseau, and BD Hammock, 2004. Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis. Archives of Biochemistry and Biophysics 430(2):247-255.
M Lydy, J Beldin, CE Wheelock, BD Hammock, and DL Denton, 2004. Challenges in regulating pesticide mixtures. Ecology and Society 9(6):1. [online] URL: http://www.ecologyandsociety.org/vol9/iss6/art1.
DL Denton, CE Wheelock, S Murray, LA Deanovic, BD Hammock, and DE Hinton, 2003. Joint acute toxicity of esfenvalerate and diazinon to fathead minnow (Pimephales promelas) larvae. Environmental Toxicology and Chemistry, 22(2):336-341.
CE Wheelock, ÅM Wheelock, R Zhang, JE Stok, C Morisseau, SE Le Valley, CE Green, and BD Hammock, 2003. Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes. Analytical Biochemistry, 315:208-222.
CE Wheelock, Y Nakagawa, M Akamatsu, and BD Hammock, 2003. Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors. Bioorganic and Medicinal Chemistry 11(23):5101-5116.
SG Kamita, AC Hinton, CE Wheelock, MD Wogulis, DK Wilson, NM Wolf, B Hock, and BD Hammock, 2003. Juvenile hormone (JH) esterase: Why are you so JH specific? Insect Biochemistry and Molecular Biology 33(12):1261-1273.
CE Wheelock, TA Baumgartner, JW Newman, MF Wolfe, and RS Tjeerdema, 2002. Effect of nutritional state on Hsp60 levels in the rotifer Brachionus plicatilis following toxicant exposure. Aquatic Toxicology, 61(1-2):89-93.
CE Wheelock, ME Colvin, I Uemura, MM Olmstead, Y Nakagawa, JR Sanborn, AD Jones, and BD Hammock, 2002. Use of ab initio calculations to predict carboxylesterase inhibitor potency. Journal of Medicinal Chemistry, 45(25):5576-5593.
CE Wheelock, TF Severson, and BD Hammock, 2001. Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. Chemical Research in Toxicology, 14(12):1563-1572.
C Morisseau, MH Goodrow, JW Newman, CE Wheelock, DL Dowdy, and BD Hammock, 2002. Structural refinement of urea based soluble epoxide hydrolase inhibitors. Biochemical Pharmacology, 63(9):1599-1608.
JW Newman, DL Denton, C Morisseau, CS Koger, CE Wheelock, DE Hinton, and BD Hammock, 2001. Evaluation of fish models of soluble epoxide hydrolase inhibition. Environmental Health Perspectives, 109(1):61-66.
Y Nakagawa, CE Wheelock, C Morisseau, MH Goodrow, BG Hammock, and BD Hammock, 2000. 3-D Analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, aryl ureas, and their analogs. Bioorganic and Medicinal Chemistry, 8(11):2663-2673.
Hsp60 induced tolerance in the rotifer, Brachionus plicatilis, exposed to multiple environmental contaminants

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